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KMID : 0614020030180010043
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Journal of Pharmaceutical Sciences (C.N.U.)
2003 Volume.18 No. 1 p.43 ~ p.48
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Formulations of Solid Lipid Microsphere of Ketorolac for Controlled Release System by Spray Drying Method
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Yoon Jae-Nam
Lee Eun-Mi
Kim Dong-Woo
Park Yong-Keun
Jeon Il-Soon
Lee Gye-Won
Jee Ung-Kil
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Abstract
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Ketorolac (KA) and ketorolac tromethamine (KT) is the nonsteroidal anti-inflammatory drugs (NSAIDs) and has been used widely. To improve its frequent administration by control of drug release. we prepared SLM of KA and KT using Mirj 45 and 52 as surfactants and tripalmitin and tristearin as lipids by spry drying method SLM, as a disperse system for injection, were evaluated by measurement of particle sizes. SEM and drug release pattern As a result. spherical SLM were prepared and their particle size were in the range of 25-125 μm, which were dependant on the types and contents of lipid and sururfactants. Their dissolution rate were decreased as increasing lipid contents.
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KEYWORD
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controlled release, solid lipid microsphere(SLM), spray drying, Myrj 45, Myrj 52
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